Which laboratory finding on CMP is commonly elevated in bone metastases and multiple myeloma?

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Prepare for the Clinical Decision-Making (CDM) Cases Part I test. Equip yourself with valuable questions and insights. Ensure success with clear explanations and strategic study tips!

Multiple Choice

Which laboratory finding on CMP is commonly elevated in bone metastases and multiple myeloma?

Explanation:
In bone-metastatic disease and multiple myeloma, malignant cells in the bone stimulate osteoclasts and promote bone destruction. As bone tissue is broken down, calcium is released into the bloodstream, leading to elevated serum calcium levels. This pattern shows up on a CMP as hypercalcemia, which is a common metabolic abnormality in these conditions. The other options don’t fit this mechanism: sodium and potassium elevations aren’t characteristically driven by bone destruction, and hypocalcemia would suggest insufficient calcium rather than release from bone.

In bone-metastatic disease and multiple myeloma, malignant cells in the bone stimulate osteoclasts and promote bone destruction. As bone tissue is broken down, calcium is released into the bloodstream, leading to elevated serum calcium levels. This pattern shows up on a CMP as hypercalcemia, which is a common metabolic abnormality in these conditions. The other options don’t fit this mechanism: sodium and potassium elevations aren’t characteristically driven by bone destruction, and hypocalcemia would suggest insufficient calcium rather than release from bone.

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