Acute interstitial nephritis is commonly associated with which medication class?

Acute interstitial nephritis is commonly associated with which medication class?

• A. NSAIDs and sulfonamide antibiotics.
• B. ACE inhibitors.
• C. Statins.
• D. Beta-blockers.

Answer: (A)

Acute interstitial nephritis is a drug-induced hypersensitivity reaction in the kidney interstitium. The most common offenders are NSAIDs and sulfonamide antibiotics, which can trigger interstitial inflammation with eosinophils and lead to a rise in creatinine. Clinically, it often appears after a period of exposure and may present with fever, rash, eosinophilia, and sterile pyuria. Because NSAIDs and sulfonamide antibiotics are the classic culprits, this option best fits the question. The other drugs listed are not typical causes of acute interstitial nephritis—they affect the kidney in different ways (ACE inhibitors more often cause hemodynamic AKI in certain settings; statins and beta-blockers are not common AIN culprits).

Acute interstitial nephritis is a drug-induced hypersensitivity reaction in the kidney interstitium. The most common offenders are NSAIDs and sulfonamide antibiotics, which can trigger interstitial inflammation with eosinophils and lead to a rise in creatinine. Clinically, it often appears after a period of exposure and may present with fever, rash, eosinophilia, and sterile pyuria. Because NSAIDs and sulfonamide antibiotics are the classic culprits, this option best fits the question. The other drugs listed are not typical causes of acute interstitial nephritis—they affect the kidney in different ways (ACE inhibitors more often cause hemodynamic AKI in certain settings; statins and beta-blockers are not common AIN culprits).